PLGA-based monolithic filaments prepared by hot-melt extrusion: In-vitro comparative study
Publication date: Available online 14 November 2017
Source:Annales Pharmaceutiques Françaises
Author(s): R. Kamel, H. Abbas
To avoid frequent drug administration, PLGA-based monolithic filament-shaped implants were prepared. In this study, the effect of different formulation variables was studied, namely: type of PLGA (PLGA 502 and PLGA 503), type of drug (the lipophilic Prednisolone acetate, PA and the hydrophilic Propranolol Hydrochloride, PH) and drug loading (10 and 30% w/w). PLGA 503-based implants showed a lower water uptake, lower mass loss and erosion, slower drug release, and...